侯丽
侯丽 [副教授]
联系方式
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电子邮箱：houli@mailbox.gxnu.edu.cn
办公地址：广西师范大学化学与药学学院分析化学教研室410
基本介绍
侯丽，博士，副教授，硕士生导师，2017年6月于福州大学药物分析学专业获得医学博士学位，同年入职广西师范大学化学与药学学院。主要从事纳米生物传感器的构建及研究工作。主持国家自然科学基金，广西自然科学基金等项目5项。目前已在国际学术期刊发表SCI论文50余篇，参编英文学术专著2部，获得4项授权国家发明专利（其中转让1项），科研成果获2022年广西自然科学奖一等奖（第六完成人）。指导多名本科生参加省部级以上学科竞赛荣获一等奖和金奖，指导多名研究生获国家奖学金、优秀三好学生和优秀毕业生等荣誉称号。
每年招收1-2名硕士研究生，热烈欢迎对本实验室课题感兴趣的同学加入！
研究方向
1. 电分析
2. 生物传感及生化分析
3. 生物成像
学历背景
起止时间 | 毕业院校 | 专业 | 学位 |
2008.09~2012.06 | 重庆三峡学院 | 化学（师范类） | 学士 |
2012.09~2017.06 | 福州大学 | 药物分析学 | 博士 |
工作经历
起止时间 | 工作单位 | 职务 |
2017.06至今 | 广西师范大学 | 专任教师 |
讲授课程
本科生课程：《分析化学》、《仪器分析》、《分析化学实验》、《仪器分析实验》、《药物分析实验》
研究生课程：《电分析化学》、《分析化学前沿》、《仪器分析实验》
入职以来发表论著
[36] Yanling Chen‡, ShanjuanXu‡, Li Hou*, Yanke Lu, Xiaojie Gao, Bo Weng*, Tianran Lin*, Shulin Zhao*, Portable self-powered dual-photoelectrode PFC aptasensor based on the“on-off-on” signal response via a digital multimeter for dual-mycotoxin assay. Microchemical Journal, 2026, 224, 117452.
[35] Yuanying Chen, Tianran Lin*, Shuangshuang He, Qi Jiao, Shulin Zhao, Li Hou*, Enzyme-free multicolor sensor for visual detection of malathion based on a bimetallic magnetic nanozyme-mediated gold nanorod etching. Food Chemistry, 2026, 498, 147258.
[34] Tianran Lin*, Xinlian Chen, Xiujuan Chen, Jincui Su, Hong Zhao, Shulin Zhao, Li Hou*, Colorimetric and photothermal dual-mode vertical flow assay for sensitive detection of Escherichia coli O157:H7 based on 4-mercaptophenylboronic acid-functionalized Cu2-xSe-Au nanozyme. Sensors and Actuators B: Chemical, 2026, 447, 138915.
[33] Qi Jiao, Zihui Xie, Yuanying Chen, Shuangshuang He, Li Hou*, Shulin Zhao, Tianran Lin*, Colorimetric and ratio-fluorescence dual-mode assay for multicolor detection of acid phosphatase based on iron ions modified hydrogen-bonded organic framework nanozymes. Analytica Chimica Acta, 2026, 1382, 344868.
[32] Yunping Lai‡, Shuangshuang He‡, Yuanying Chen, Tianran Lin*, Li Hou*, Shulin Zhao, Hydrogen-bonded organic framework nanozyme with multi-enzyme activity for chemiluminescence sensing of acetylcholinesterase and screening its inhibitors. Analytical Chemistry 2025, 97, 8362−8369.
[31] Jiamin Huang‡, Hong Zhao‡, Xinlian Chen, Tianran Lin*, Li Hou*, Shulin Zhao, Pt nanoparticles functionalized hydrogen-bonded organic frameworks: Athree-in-one nanozyme for colorimetric detection of alkaline phosphatase. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2025, 333, 125894.
[30] Xinlian Chen, Tianran Lin*, Jincui Su, Li Hou*, Shulin Zhao, Boric acid functionalized Cu2-xSe nanozyme for the immunomagnetic bead-based colorimetric assay of Escherichia coli O157:H7 coupledwith smartphone. Microchemical Journal 2025, 209, 112713.
[29] Shendong Liu‡, Xinlian Chen‡, Hong Zhao, Tianran Lin*, Li Hou*, Shulin Zhao, Rapid photothermal assay for ultrasensitive point‑of‑care detectionof tumor markers based on a filter membrane. Microchimica Acta 2024, 191, 522.
[28] Fenghuang Wei, Li Hou*, Yiyun Yao, Yunping Lai, Tianran Lin*, Shulin Zhao, Dianping Tang, An intelligent Cu/ZIF‑8‑based nanodrug delivery systemfor tumor‑specific and synergistic therapy via tumor microenvironment‑responsive cascade reaction. Microchimica Acta 2024, 191, 447.
[27] Min Wang‡, Xiaojie Gao‡, Li Hou*, Yanling Chen, Tianran Lin*, A novel split-type photoelectrochemical biosensor based onliposome-induced in situ formation of Bi2S3@BiOI/Ag2S heterojunction forthe sensitive detection of CEA. Microchemical Journal 2024, 200, 110388.
[26] Min Wang‡, Yanling Chen‡, Yijin Huang, Li Hou*, Shulin Zhao, Tianran Lin*, A self-powered photoelectrochemical aptasensor based on target responseand Ag-CdIn2S4 photosensitive material for ultrasensitive detection of prostate-specific antigen. Microchemical Journal 2024, 205, 111278.
[25] Xinlian Chen, Na Li, Tianran Lin*, Jiamin Huang, Li Hou*, Shulin Zhao, An off–on fluorescence sensor based on hydrogen-bonded organicframeworks for the detection of glutathione. Microchemical Journal 2024, 196, 109555.
[24] Tianran Lin*, Yunping Lai, Gaoyan Jiang, Xinlian Chen, Li Hou*, Shulin Zhao*, pH-Triggered visual detection of Escherichia colibased on the co-assembly of bacitracin andthymolphthalein. Chemical Communications 2023, 59, 12986-12989.
[23] Yunping Lai‡, Beirong Yu‡, Tianran Lin*, Li Hou*, Iodide-mediated etching of gold nanostar for the multicolor visual detection of hydrogen peroxide. Biosensors 2023, 13, 585.
[22] Yiyun Yao, Li Hou*, Fenghuang Wei, Tianran Lin*, Shulin Zhao, An intelligent readable and capture-antibody-independent lateral flow immunoassay based on Cu2− xSe nanocrystals for point-of-care detection of Escherichia coli O157: H7. Analyst 2024, 149, 357-365.
[21] Juanjuan Huang‡, Yanling Chen‡, Li Hou*, Tianran Lin*, A methylene blue-functionalized DNA concatemer for the construction of a turn-off fluorescent immunosensor for the sensitive detection of carcinoembryonic antigen. Analytical Methods 2023, 15, 4215-4219.
[20] Li Hou, Xiaoyu Chen, Xuanhan Zhang, Yufang Tang, Yiyun Yao, Tianran Lin*, Shulin Zhao*, Zn-ZrMOF containing Lewis acid-base catalytic sites for hydrolysis and visual detection of profenofos. Sensors and Actuators B: Chemical 2023, 375, 132902.
[19] JiayaoXu‡, Yuxin Qin‡, Qiuyi Liang, Xiaohong Zhong, Li Hou*,Yong Huang*, Shulin Zhao, Hong Liang*, A MnOx-nucleic acid nanoprobe with enzyme-free cascade signal amplification for ultrasensitive intracellular microRNA imaging. Chemical Communications 2022, 58, 12883.
[18] Juanjuan Huang‡, FenghuangWei‡, Yuling Cui, Li Hou*, Tianran Lin*, Fluorescence immunosensor based on functional nanomaterials and its application in tumor biomarker detection. RSC Advances 2022, 12, 31369.
[17] Xiaoyan Jiang‡, Min Wang‡, Li Hou*, Tianran Lin*, An ordered one-step colorimetric sensor for selective determination of catechol based on the polyacrylic acid-coated cerium oxide with laccase-like activity. New Journal of Chemistry 2022, 46, 22412.
[16] Tianran Lin*, Gaoyan Jiang, Danxuan Lin, Yunping Lai, Li Hou*, Shulin Zhao*, Bacitracin-functionalized dextran-MoSe2 with peroxidase-like and near-infrared photothermal activities for low-temperature and synergetic antibacterial applications. ACS Appl. Bio Mater. 2022, 5, 5, 2347-2354.
[15] Tianran Lin*, Chunsuo Tian, Ying Sun, Shendong Liu, Di Wang, Li Hou*, Shulin Zhao, Information encryption with a high information-carrying capacity based on astimulus-responsive hydrogen-bonded organic framework and a smartphone. Chinese Chemical Letters 2022, 441, 136092.
[14] Min Wang, Li Hou*, Xiaoyu Chen, Tianran Lin*, Homogeneous photoelectrochemical biosensor for sensitive detection of omethoate via ALP-mediated pesticide assay and Bi2S3@Bi2Sn2O7 heterojunction as photoactive material. Analytical and Bioanalytical Chemistry 2022, 414, 7277-7289.
[13] Tianran Lin*, Ying Sun, Chunsuo Tian, Di Wang, Li Hou*, Fanggui Ye*, ShulinZhao, A silk-like hydrogen-bonded organic framework functionalized membrane with intrinsic catalytic activity for nonmetallic reduction of 4-nitrophenol. Chemical Engineering Journal 2022, 441, 136092.
[12] Juanjuan Huang‡, Yiyun Yao‡, Yanling Chen, Tianran Lin, Li Hou*, Dianping Tang*, Polydopamine-functionalized copper peroxide/ZIF-8 nanoparticle-based fluorescence-linked immunosorbent assay for the sensitive determination of carcinoembryonic antigen by self-supplied H2O2 generation. Biosensors 2022, 12, 830.
[11] Li Hou, Yuanlin Huang, Tianran Lin*, Fanggui Ye*, Shulin Zhao, A FRET ratiometric fluorescence biosensor for the selective determinationof pyrophosphate ion and pyrophosphatase activity based on difunctional Cu-MOF nanozyme. Biosensors and Bioelectronics: X 2022, 10, 100101.
[10] Tianran Lin*, Shendong Liu , Juanjuan Huang , Chunsuo Tian, Li Hou*, Fanggui Ye, Shulin Zhao, Multicolor and photothermal dual-mode assay of alkaline phosphatase based on the UV light-assisted etching of goldnanorods. Analytica Chimica Acta 2021, 1181.
[9] Li Hou, Xuanhan Zhang, Yuxiu Huang, Min Wang, Xiaoyu Chen,Tianran Lin*, Yanhui Tan*,Shulin Zhao*, A ratiometric electrochemical biosensor via alkalinephosphatase mediated dissolution of nano-MnO2 and Ru(III) redox recycling forthe determination of dimethoate. Journal of Pharmaceutical and Biomedical Analysis 2021, 207, 114400.
[8] Li Hou*, Juanjuan Huang, Shendong Liu, Tianran Lin*, Shulin Zhao*, Magneto-controlled fluorescent immunosensor forsensitive determination of biomarker via three-dimensional AuNCs/liposomenetworks. Sensors and Actuators B: Chemical 2021, 342, 130075.
[7] Gaoyan Jiang, Tianran Lin*, Yuxin Qin, XuanhanZhang, Li Hou*, Ying Sun, JuanjuanHuang, Shendong Liu, Shulin Zhao*, Accelerating the peroxidase-like activity of MoSe2 nanosheets at physiological pH by dextran modification. Chemical Communications 2020, 56, 10847-10850.
[6] Li Hou, Yuemei Qin, TianranLin*, Ying Sun, Fanggui Ye*, Shulin Zhao, Michael reaction-assisted fluorescentsensor for selective and one step determination of catechol via bifunctionalFe-MIL-88NH2 nanozyme. Sensors and Actuators B: Chemical 2020, 321,128547.
[5] Li Hou, Xuanhan Zhang, Man Kong, Gaoyan Jiang, Ying Sun, Weiming Mo, Tianran Lin*, Fanggui Ye, Shulin Zhao*, A competitive immunoassay for electrochemical impedimetric determination of chlorpyrifos using a nanogold-modified glassy carbon electrode based on enzymatic biocatalytic precipitation. Microchimica Acta 2020, 187, 204.
[4] Li Hou, Gaoyan Jiang, Ying Sun, Xuanhan Zhang, Juanjuan Huang, Shendong Liu, Tianran Lin*, Fanggui Ye, Shulin Zhao*, Process and trend on the regulation methods for nanozyme activity and its application. Catalysts 2019, 9, 1057.
[3] Li Hou, Yuxin Qin, Jinying Li, Siyuan Qin, Yuanlin Huang, Tianran Lin*, Liangqia Guo, Fanggui Ye, Shulin Zhao, A ratiometric multicolor fluorescence biosensor for visual detection of alkaline phosphatase activity via a smartphone. Biosensors and Bioelectronics 2019, 143, 111605.
[2] Tianran Lin, Danxuan Lin, Li Hou, Fluorescence measurements, imaging and counting by a smartphone[M]//Smartphone-Based Detection Devices. Elsevier, 2021: 57-72.
[1] Xiaoping Wu, Li Hou, Xucong Lin, Zenghong Xie, Chapter 12 - Application of Novel Nanomaterials for Chemo- and Biosensing of Algal Toxins in Shellfish and Water, Editor(s): Xiaoru Wang, Xi Chen,In Micro and Nano Technologies, Novel Nanomaterials for Biomedical, Environmental and Energy Applications, Elsevier, 2019, Pages 353-414, ISBN 9780128144978, https://doi.org/10.1016/B978-0-12-814497-8.00012-6.
授权发明专利
1.侯丽，王敏，高小洁，林天然，赵书林.一种自供能光电化学适配体传感器的制备方法及应用.ZL2023109183134
2.侯丽，王敏，高小洁，林天然，赵书林.一种检测癌胚抗原的光电化学免疫传感器的制备方法及其应用.ZL2023109183685
3.侯丽，张宣晗，范敏，蒋高艳，林天然，赵书林.一种基于Cu-ZrMOF的多模式信号检测蔬菜中毒死蝉含量的方法ZL2020110260299
4.侯丽，黄娟娟，蒋高艳，林天然，赵书林.一种磁控荧光生物传感器的制备方法及其应用.ZL2021102515303（技术转让）
主持科研项目
1. 国家自然科学基金地区基金：纳米材料辅助多重信号放大的电化学/可视化多模式高灵敏传感器研究（项目批准号：21964004,2020.01-2023.12）
2. 广西自然科学基金面上项目：抗菌肽辅助剥离的二维过渡金属硫族纳米酶及其协同抗菌与检测细菌研究（项目批准号：2022GXNSFAA035475, 2022.04-2025.03）
3. 广西自然科学基金青年项目：基于多重信号放大的磁控多模式传感平台用于有机磷农药残留分析（项目批准号：2018GXNSFBA050053，2019.03-2022.02）
4. 广西自然科学基金面上项目：便携式光电化学传感平台的构建及其对真菌毒素的高通量检测研究（项目批准号：2025GXNSFAA069159，2025.03-2028.02）
5. 广西师范大学自然科学重点项目：功能化分级孔MOFs电化学传感平台的构建及其用于有机磷农药残留分析（项目批准号：2017ZD005，2018.01-2020.12）
6. 广西师范大学国家自然科学基金联合培育项目：HOFs基便携式光电化学/电致变色传感平台对真菌毒素的检测研究(项目批准号：2025PY023，2025.12-2026.12)
7. 食品安全与生物分析教育部重点实验室开放课题：基于金属有机骨架材料的电化学信号放大技术检测肽类兴奋剂（项目批准号：FS1806，2018.01-2019.12）
8. 食品安全与生物分析教育部重点实验室开放课题：HOFs基便携式光电化学/电致变色传感平台对食源性真菌毒素的检测研究（项目批准号：FS2501，2025.07-2027.06）
获奖情况
1. 2022年广西自然科学奖一等奖（第六完成人）
2. 第十二届全国大学生电子商务“创新、创意及创业”挑战赛广西赛区省级选拔赛优秀指导老师，2022年
3. 第九届中国国际互联网+大学生创新创业大赛“数广集团杯”广西赛区选拔赛优秀创新创业导师，2023年
主持教改项目
1. 2025年校级本科生教改课题重点项目（项目编号：2025JGZ12）
2. 2025年校级本科生课程思政示范课程——现代仪器分析实验（项目编号：2025kcsz36）
3. 2021年校级本科生教改课题一般项目A类（项目编号：2021JGA20）
指导学生情况
1. 中国国际大学生创新大赛“建行杯”广西赛区选拔赛银奖（2025年）
2. 第十五届中国大学生服务外包创新创业大赛全国赛创响无锡类三等奖（2024年）
3. 第九届中国国际互联网+大学生创新创业大赛“数广集团杯”广西赛区金奖（2023年）
4. 第四届全国大学生化学实验创新设计大赛“微瑞杯”华南赛区一等奖（2023年）
5. 第十二届全国大学生电子商务“创新、创意及创业”挑战赛广西赛区一等奖及最佳创新奖（2022年）
6. 第十届“挑战杯”广西大学生创业计划竞赛银奖（2022年）
7. 第八届中国国际“互联网+”大学创新创业大赛“数广集团杯”广西赛区铜奖（2022年）
8. 第十届广西高校大学生化学实验技能竞赛一等奖1项、二等奖3项（2019年）
9. 第九届广西高校大学生化学实验技能竞赛一等奖2项、二等奖1项、三等奖1项（2017年）
10.大学生创新创业训练计划项目3项（国家级1项，区级2项）