侯丽
侯丽 [副教授]
联系方式
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电子邮箱:houli@mailbox.gxnu.edu.cn
办公地址:广西师范大学化学与药学学院分析化学教研室410
基本介绍
侯丽,博士,副教授,硕士生导师,2017年6月于福州大学药物分析学专业获得医学博士学位,同年入职广西师范大学化学与药学学院。主要从事纳米生物传感器的构建及研究。主持国家自然科学基金,广西自然科学基金等项目5项。目前已在国际学术期刊发表SCI论文50余篇,参编英文学术专著2部,获得1项授权国家发明专利。
每年招收1-2名硕士研究生,热烈欢迎对本实验室课题感兴趣的同学加入!
研究方向
1. 电分析
2. 生物传感及生化分析
3. 生物成像
学历背景
起止时间 | 毕业院校 | 专业 | 学位 |
2008.09~2012.06 | 重庆三峡学院 | 化学(师范类) | 学士 |
2012.09~2017.06 | 福州大学 | 药物分析学 | 博士 |
工作经历
起止时间 | 工作单位 | 职务 |
2017.06至今 | 广西师范大学 | 专任教师 |
讲授课程
本科生课程:《分析化学》、《仪器分析》、《分析化学实验》、《仪器分析实验》、《药物分析实验》
研究生课程:《电分析化学》、《分析化学前沿》、《仪器分析实验》
入职以来发表论著
[32] Yunping Lai‡, Shuangshuang He‡, Yuanying Chen, Tianran Lin*, Li Hou*, Shulin Zhao, Hydrogen-bonded organic framework nanozyme with multi-enzyme activity for chemiluminescence sensing of acetylcholinesterase and screening its inhibitors. Analytical Chemistry 2025, 97, 8362−8369.
[31] Jiamin Huang‡, Hong Zhao‡, Xinlian Chen, Tianran Lin*, Li Hou*, Shulin Zhao, Pt nanoparticles functionalized hydrogen-bonded organic frameworks: Athree-in-one nanozyme for colorimetric detection of alkaline phosphatase. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2025, 333, 125894.
[30] Xinlian Chen, Tianran Lin*, Jincui Su, Li Hou*, Shulin Zhao, Boric acid functionalized Cu2-xSe nanozyme for the immunomagnetic bead-based colorimetric assay of Escherichia coli O157:H7 coupledwith smartphone. Microchemical Journal 2025, 209, 112713.
[29] Shendong Liu‡, Xinlian Chen‡, Hong Zhao, Tianran Lin*, Li Hou*, Shulin Zhao, Rapid photothermal assay for ultrasensitive point‑of‑care detectionof tumor markers based on a filter membrane. Microchimica Acta 2024, 191, 522.
[28] Fenghuang Wei, Li Hou*, Yiyun Yao, Yunping Lai, Tianran Lin*, Shulin Zhao, Dianping Tang, An intelligent Cu/ZIF‑8‑based nanodrug delivery systemfor tumor‑specific and synergistic therapy via tumor microenvironment‑responsive cascade reaction. Microchimica Acta 2024, 191, 447.
[27] Min Wang‡, Xiaojie Gao‡, Li Hou*, Yanling Chen, Tianran Lin*, A novel split-type photoelectrochemical biosensor based onliposome-induced in situ formation of Bi2S3@BiOI/Ag2S heterojunction forthe sensitive detection of CEA. Microchemical Journal 2024, 200, 110388.
[26] Min Wang‡, Yanling Chen‡, Yijin Huang, Li Hou*, Shulin Zhao, Tianran Lin*, A self-powered photoelectrochemical aptasensor based on target responseand Ag-CdIn2S4 photosensitive material for ultrasensitive detection of prostate-specific antigen. Microchemical Journal 2024, 205, 111278.
[25] Xinlian Chen, Na Li, Tianran Lin*, Jiamin Huang, Li Hou*, Shulin Zhao, An off–on fluorescence sensor based on hydrogen-bonded organicframeworks for the detection of glutathione. Microchemical Journal 2024, 196, 109555.
[24] Tianran Lin*, Yunping Lai, Gaoyan Jiang, Xinlian Chen, Li Hou*, Shulin Zhao*, pH-Triggered visual detection of Escherichia colibased on the co-assembly of bacitracin andthymolphthalein. Chemical Communications 2023, 59, 12986-12989.
[23] Yunping Lai‡, Beirong Yu‡, Tianran Lin*, Li Hou*, Iodide-mediated etching of gold nanostar for the multicolor visual detection of hydrogen peroxide. Biosensors 2023, 13, 585.
[22] Yiyun Yao, Li Hou*, Fenghuang Wei, Tianran Lin*, Shulin Zhao, An intelligent readable and capture-antibody-independent lateral flow immunoassay based on Cu2− xSe nanocrystals for point-of-care detection of Escherichia coli O157: H7. Analyst 2024, 149, 357-365.
[21] Juanjuan Huang‡, Yanling Chen‡, Li Hou*, Tianran Lin*, A methylene blue-functionalized DNA concatemer for the construction of a turn-off fluorescent immunosensor for the sensitive detection of carcinoembryonic antigen. Analytical Methods 2023, 15, 4215-4219.
[20] Li Hou, Xiaoyu Chen, Xuanhan Zhang, Yufang Tang, Yiyun Yao, Tianran Lin*, Shulin Zhao*, Zn-ZrMOF containing Lewis acid-base catalytic sites for hydrolysis and visual detection of profenofos. Sensors and Actuators B: Chemical 2023, 375, 132902.
[19] JiayaoXu‡, Yuxin Qin‡, Qiuyi Liang, Xiaohong Zhong, Li Hou*,Yong Huang*, Shulin Zhao, Hong Liang*, A MnOx-nucleic acid nanoprobe with enzyme-free cascade signal amplification for ultrasensitive intracellular microRNA imaging. Chemical Communications 2022, 58, 12883.
[18] Juanjuan Huang‡, FenghuangWei‡, Yuling Cui, Li Hou*, Tianran Lin*, Fluorescence immunosensor based on functional nanomaterials and its application in tumor biomarker detection. RSC Advances 2022, 12, 31369.
[17] Xiaoyan Jiang‡, Min Wang‡, Li Hou*, Tianran Lin*, An ordered one-step colorimetric sensor for selective determination of catechol based on the polyacrylic acid-coated cerium oxide with laccase-like activity. New Journal of Chemistry 2022, 46, 22412.
[16] Tianran Lin*, Gaoyan Jiang, Danxuan Lin, Yunping Lai, Li Hou*, Shulin Zhao*, Bacitracin-functionalized dextran-MoSe2 with peroxidase-like and near-infrared photothermal activities for low-temperature and synergetic antibacterial applications. ACS Appl. Bio Mater. 2022, 5, 5, 2347-2354.
[15] Tianran Lin*, Chunsuo Tian, Ying Sun, Shendong Liu, Di Wang, Li Hou*, Shulin Zhao, Information encryption with a high information-carrying capacity based on astimulus-responsive hydrogen-bonded organic framework and a smartphone. Chinese Chemical Letters 2022, 441, 136092.
[14] Min Wang, Li Hou*, Xiaoyu Chen, Tianran Lin*, Homogeneous photoelectrochemical biosensor for sensitive detection of omethoate via ALP-mediated pesticide assay and Bi2S3@Bi2Sn2O7 heterojunction as photoactive material. Analytical and Bioanalytical Chemistry 2022, 414, 7277-7289.
[13] Tianran Lin*, Ying Sun, Chunsuo Tian, Di Wang, Li Hou*, Fanggui Ye*, ShulinZhao, A silk-like hydrogen-bonded organic framework functionalized membrane with intrinsic catalytic activity for nonmetallic reduction of 4-nitrophenol. Chemical Engineering Journal 2022, 441, 136092.
[12] Juanjuan Huang‡, Yiyun Yao‡, Yanling Chen, Tianran Lin, Li Hou*, Dianping Tang*, Polydopamine-functionalized copper peroxide/ZIF-8 nanoparticle-based fluorescence-linked immunosorbent assay for the sensitive determination of carcinoembryonic antigen by self-supplied H2O2 generation. Biosensors 2022, 12, 830.
[11] Li Hou, Yuanlin Huang, Tianran Lin*, Fanggui Ye*, Shulin Zhao, A FRET ratiometric fluorescence biosensor for the selective determinationof pyrophosphate ion and pyrophosphatase activity based on difunctional Cu-MOF nanozyme. Biosensors and Bioelectronics: X 2022, 10, 100101.
[10] Tianran Lin*, Shendong Liu , Juanjuan Huang , Chunsuo Tian, Li Hou*, Fanggui Ye, Shulin Zhao, Multicolor and photothermal dual-mode assay of alkaline phosphatase based on the UV light-assisted etching of goldnanorods. Analytica Chimica Acta 2021, 1181.
[9] Li Hou, Xuanhan Zhang, Yuxiu Huang, Min Wang, Xiaoyu Chen,Tianran Lin*, Yanhui Tan*,Shulin Zhao*, A ratiometric electrochemical biosensor via alkalinephosphatase mediated dissolution of nano-MnO2 and Ru(III) redox recycling forthe determination of dimethoate. Journal of Pharmaceutical and Biomedical Analysis 2021, 207, 114400.
[8] Li Hou*, Juanjuan Huang, Shendong Liu, Tianran Lin*, Shulin Zhao*, Magneto-controlled fluorescent immunosensor forsensitive determination of biomarker via three-dimensional AuNCs/liposomenetworks. Sensors and Actuators B: Chemical 2021, 342, 130075.
[7] Gaoyan Jiang, Tianran Lin*, Yuxin Qin, XuanhanZhang, Li Hou*, Ying Sun, JuanjuanHuang, Shendong Liu, Shulin Zhao*, Accelerating the peroxidase-like activity of MoSe2 nanosheets at physiological pH by dextran modification. Chemical Communications 2020, 56, 10847-10850.
[6] Li Hou, Yuemei Qin, TianranLin*, Ying Sun, Fanggui Ye*, Shulin Zhao, Michael reaction-assisted fluorescentsensor for selective and one step determination of catechol via bifunctionalFe-MIL-88NH2 nanozyme. Sensors and Actuators B: Chemical 2020, 321,128547.
[5] Li Hou, Xuanhan Zhang, Man Kong, Gaoyan Jiang, Ying Sun, Weiming Mo, Tianran Lin*, Fanggui Ye, Shulin Zhao*, A competitive immunoassay for electrochemical impedimetric determination of chlorpyrifos using a nanogold-modified glassy carbon electrode based on enzymatic biocatalytic precipitation. Microchimica Acta 2020, 187, 204.
[4] Li Hou, Gaoyan Jiang, Ying Sun, Xuanhan Zhang, Juanjuan Huang, Shendong Liu, Tianran Lin*, Fanggui Ye, Shulin Zhao*, Process and trend on the regulation methods for nanozyme activity and its application. Catalysts 2019, 9, 1057.
[3] Li Hou, Yuxin Qin, Jinying Li, Siyuan Qin, Yuanlin Huang, Tianran Lin*, Liangqia Guo, Fanggui Ye, Shulin Zhao, A ratiometric multicolor fluorescence biosensor for visual detection of alkaline phosphatase activity via a smartphone. Biosensors and Bioelectronics 2019, 143, 111605.
[2] Tianran Lin, Danxuan Lin, Li Hou, Fluorescence measurements, imaging and counting by a smartphone[M]//Smartphone-Based Detection Devices. Elsevier, 2021: 57-72.
[1] Xiaoping Wu, Li Hou, Xucong Lin, Zenghong Xie, Chapter 12 - Application of Novel Nanomaterials for Chemo- and Biosensing of Algal Toxins in Shellfish and Water, Editor(s): Xiaoru Wang, Xi Chen,In Micro and Nano Technologies, Novel Nanomaterials for Biomedical, Environmental and Energy Applications, Elsevier, 2019, Pages 353-414, ISBN 9780128144978, https://doi.org/10.1016/B978-0-12-814497-8.00012-6.
主持科研项目
国家自然科学基金地区基金(项目批准号:21964004,2020.01-2023.12)
广西自然科学基金面上项目(项目批准号:2022GXNSFAA035475, 2022.04-2025.03)
广西自然科学基金青年项目(项目批准号:2018GXNSFBA050053,2019.03-2022.02)
广西自然科学基金面上项目(项目批准号:2025GXNSFAA069159,2025.03-2028.02)
广西师范大学自然科学重点项目(项目批准号:2017ZD005,2018.01-2020.12)
食品安全与生物分析教育部重点实验室开放课题(项目批准号:FS1806,2018.01-2019.12)
食品安全与生物分析教育部重点实验室开放课题(项目批准号:FS2501,2025.07-2027.06)