联系方式：电子邮箱：chenhuagnu@gxnu.edu.cn；chenhua_jsu@163.com实验室地址：国重室1号楼608
基本介绍
陈华，教授，博士生导师，广西首批“八桂青年拔尖人才”和广西杰出青年基金获得者,中国化学会高级会员。先后于江苏大学和湖南大学获得学士和博士学位。随后加入广西师范大学化学与药学学院从事教学与科研工作。主要从事功能染料分子结构调控与生物成像应用，分子探针与生物成像研究。相关研究成果在J. Am. Chem. Soc., Angew. Chem., Acc. Chem. Res., Adv. Funct. Mater., Chem. Sci., Anal. Chem., Adv. Healthc. Mater.等重要SCI期刊发表论文40余篇，曾入选ESI高被引论文4篇和热点论文2篇。研究成果获得了国内外同行的广泛关注，SCI他引2500余次，单篇最高引用次数261次，单篇引用次数大于100的论文5篇。授权国家发明专利7项，转让1项。先后主持国家自然科学基金3项和省部级项目3项。受邀担任Wiley旗下生物材料期刊VIEW青年编委， Frontiers in Bioengineering and Biotechnology客座编辑, ACS、RSC、Wiley和Elsevier等旗下期刊的审稿专家。
每年招收多名硕士研究生（包含调剂）和本科生，实验室多名研究生获国家奖学金和继续攻读博士学位，热忱欢迎有志从事科研工作的学生加入！
招生方向：有机化学/化学生物学/生物与医药
研究方向
1.功能染料结构调控与成像
2.分子探针与生物成像
奖励及荣誉
八桂青年拔尖人才（2024）
广西杰出青年科学基金（2023）
2022年广西师范大学“诚华青年教师”奖
讲授课程
有机化学实验，波谱分析，大学化学，综合化学实验，化学信息学
学术成果
Selected research papers：
1.Hua Chen* and co-workers,Bioorthogonal Reaction of β-Chloroacroleins with meta-Aminothiophenol to Develop Near-Infrared Fluorogenic Probes for Simultaneous Two-color Imaging,Journal of the American Chemical Society,2025,DOI: 10.1021/jacs.4c16074.
2.Hua Chen* and co-workers,NIR-II Fluorescence/Photoacoustic Dual Ratiometric Probes withUnique Recognition Site for Quantitatively Visualizing H2S2 in Vivo，Angewandte Chemie International Edition, 2025,64, e202418378.
3.Hua Chen* and co-workers,Deep-NIR to NIR-II Hemicyanine Fluorophore Scaffolds with Dual Optically Tunable Sites for in Vivo Multiplexed Imaging. Chem. Sci., 2025, https://doi.org/10.1039/D5SC06690E.
4.Hua Chen* and co-workers,Analyte-Induced pK
5.Hua Chen* and co-workers,Dual Ratiometric Single-Molecule Theranostic Probes forPhotothermal Therapy and Real-Time Quantitative Evaluation ofTherapeutic Efficacy In Vivo，Anal. Chem. 2025, 10.1021/acs.analchem.5c02253.
6.Hua Chen* and co-workers,Protein-Interference-Free and Kidney-Targeting NIR Fluorophores for Accurate In Vivo lmaging of H2S2 During Kidney Ferroptosis，Advanced Healthcare Materials, 2025, DOI: 10.1002/adhm.202500273
7.Hua Chen* and co-workers,Engineering of Kidney-Targeting Fluorophores with Tunable Emission from NIR-I to NIR-II for Early Diagnosis of Kidney Disease, Advanced Healthcare Materials, 2024, 10.1002/adhm.202402828
8.Hua Chen* and co-workers,Dual-Labeled Single Fluorescent Probes for the Simultaneous Two-Color Visualization of Dual Organelles and for Monitoring Cell Autophagy，Anal. Chem. 2024, 96, 876–886
9.Hua Chen* and co-workers,A General Approach to Design Dual Ratiometric Fluorescentand Photoacoustic Probe for Quantitatively Visualizing TumorHypoxia Levels in Vivo, Angewandte Chemie International Edition, 2022,61, e202107076.
10.Hua Chen and co-workers,A unique integration strategy for the rational design of optically tunable near-infrared fluorophores, Accounts of Chemical Research,2017, 50, 1410-1422
11.Hua Chen and co-workers,Development of a unique class of spiro-type two-photon fluorophores and their applications for sensing and bioimaging, Advanced Functional Material，2016, 44, 8128-8136
12.Hua Chen and co-workers,Single near-infrared fluorescent probe with high and low sensitivity sites for sensing different concentration ranges of biological thiols with distinct modes of fluorescence signals,Chemical Science,2016, 7, 1896-1903. Top 50 Articles of 2016: Analytical, Biological and Medicinal Chemistry
全部文章：Hua CHEN - Web of Science Core Collection (clarivate.cn)
科研项目
（1）广西自然科学基金杰出青年基金项目：分子探针与生物成像 （2023.6-2027.6）。
（2）国家自然科学基金项目：同步诱导和原位监测胰腺癌铁死亡的智能分子探针研制及性能研究（2025.1-2028.12）。
（3）国家自然科学基金项目：基于多通道比率型单荧光探针的过氧化亚硝酰和一氧化氮同步检测及成像（2019.1-2021.12，结题）。
（4）国家自然科学基金项目：双色同步靶向线粒体和溶酶体的帕金森荧光探针研制及其生物成像研究（2022.1-2025.12）。
（5）八桂青年拔尖人才培养项目（2024.9-2027.9）
（6）广西自然科学基金青年基金项目：新型红光发射双光子荧光染料的构建及其识别多硫化氢的生物成像研究（结题）。
（7）广西科技基地和人才专项：比率型分子探针用于重要活性氮物种的同时探测及成像研究（结题）。