联系方式

 电子邮箱：wy198565@163.com

 办公地址：国重室2号楼403

基本介绍

王艳，女，1985年6月出生，江苏徐州人。2023年3月以第五层次人才入职广西师范大学化学与药学学院任专任教师/省部共建药用资源化学与药物分子工程国家重点实验室科研人员，从事以天然产物化学为主，结合化学与生物催化结构修饰为辅的研究方向。2014年6月毕业于北京协和医学院/清华大学医学部，获理学博士学位。2014年7月至2019年2月在中国农业科学院农产品加工研究所工作，任助理研究员。2018年1月-2019年2月在巴基斯坦卡拉奇大学国际化学与生命科学研究院开展博士后研究；2019年3月至2023年2月在巴基斯坦卡拉奇大学国际化学与生命科学研究院工作，任助理教授/博士生导师。迄今主持及副主持巴基斯坦NRPU项目(相当于国自然)、政府间国际合作等项目9项；以第一或通讯作者发表SCI论文27篇；参编著作7部；授权专利16项；作为导师或副导师培养硕博士研究生14名（包括在读），联合培养国际交换生6名。在巴工作五年间，作为主要协调人建立了多个中-巴医药合作平台，在中巴科技合作方面发挥重要协调作用。2020年荣获巴基斯坦卡拉奇大学国际化学与生命科学研究院中巴纽带特殊贡献奖，2020年至今任国家中医药管理局中国-巴基斯坦中医药合作中心-巴方秘书长，2019-2022年任西南医科大学附属中医院客座教授，任Phytomedicine、Phytotherapy Research、MDPI系列、Natural Product Research等杂志审稿人。     

研究方向

 （1）天然产物化学

 （2）化学与生物催化结构修饰

 讲授课程

 （1）本科生课程：天然产物化学、波谱分析

 （2）研究生课程：有机波谱学、现代化学进展之天然药物化学部分（英文授课）

近五年代表性论文

1. Qian Lan#, Shuang He#, Jin-Long Liu, Yan Wang*, Dong Liang*. A neolignan enantiomer from Piper hancei with anti-neuroinflammatory effect by attenuating NF-κB signaling pathway. Phytomedicine. (In press).

2.  Ya-Jie Hu, Qian Lan, Bao-Jun Su, Yan Wang*, Dong Liang*. Three new phenolic glycosides and a new lignan glycoside from Gaultheria leucocarpa var. yunnanensis. Fitoterapia. 2024, 172: 105740.

3. Lu-Mei Dai, Shuang He, Bin Zhang, Heng-Shan Wang, Yan Wang*, Dong Liang*. Foegraecumoside O and P, a pair of triterpenoid saponins with a 4/5/6 fused tricyclic oleanane carbon skeleton from Lysimachia foenum-graecum Hance. Molecules. 2023, 28: 5061.

4. Hao Su, Ya-Jie Hu, Xiao-Yu Mo, Ning Diao, Yan Wang*, Dong Liang*. Three new phenylpropanoid glucosides and a newtyramine-type alkamide from Piper puberulum. Journal of Asian Natural Products Research. 2023, DOI: 10.1080/10286020.2023.2266386.（于德泉院士纪念专刊）

5. Farooq-Ahmad Khan*, Rimsha Irshad, Nimra Tanveer, Sana Yaqoob, Razaullah, Raza Ali, Nida Ali, Jafar Saifullah, Khwaja Ali Hasan*, Shahida Naz, Abdul Qadir, Almas Jabeen, Yan Wang*. Unleashing the potential of vanillic acid: A new twist on nature’s recipe to fight inflammation and circumvent azole-resistant fungal infections. Bioorganic Chemistry. 2024, 145, 107254.

6. Ahmed Saeed Kabbashi#, Maazah Abdul Sattar#, Muhammad Aamer, Nimra Naz Siddiqui, Muhammad Kamran, Aneela Fayaz, Humera Jahan, Farooq-Ahmad Khan*, Yan Wang*. Clerodane Furanoditerpenoids from Tinospora bakis (A.Rich.) Miers (Menispermaceae). Molecules. 2024, 29: 154.  

7. Farooq-Ahmad Khan*, Sana Yaqoob, Muhammad Wasim Qasim, Shujaat Ali, Yan Wang*, Zi-Hua Jiang*. A robust, gram-scale and high yield synthesis of MDP congeners for the activation of NOD2 receptor and vaccine adjuvantation. Synthesis. 2023, doi: 10.1055/a-2004-5883.

8. Raza Ali, Kayode Muritala Salawu, Muhammad Aamer, Humera Jahan, Priya Tufail, Rimsha Irshad, Farooq-Ahmad Khan, Bilge Sener, M. Iqbal Choudhary, Yan Wang*. A new sesquiterpene, prosoterpene, from Prosopis africana (Guill. & Perr.) Taub. Natural Product Research. 2023, 37(19): 3220-3227.

9. Ibrahim Abdurrahman Adam, Rimsha Irshad, Atia-tul-Wahab, Damilola Alex Omoboyowa, M. Iqbal Choudhary, Yan Wang*. Two new 5 (14)-membered type cyclopeptide alkaloids from root bark of Ziziphus spina-christi (L.) Desf. Natural Product Research. 2023, 37(15): 2473-2479.

10. Muhammad Aamer, Mahwish Siddiqui, Almas Jabeen, Rimsha Irshad, Farooq-Ahmad Khan, Atia-tul-Wahab, M. Iqbal Choudhary*, Yan Wang*. New anti-inflammatory and non-cytotoxic metabolites of methylstenbolone obtained by microbial transformation. Bioorganic Chemistry. 2022, 129: 106187.  

11. Nida Ali, Farooq-Ahmad Khan, Kayode M. Salawu, Rimsha Irshad, Almas Jabeen, Chun-Lei Zhang, Muhammad I. Choudhary, Xin-Min Liu*, Yan Wang*. Phytochemical Characterizations of Maranthes polyandra (Benth.) Prance. Molecules. 2022,27(4): 1316.

12. Muhammad Aamer, Mahwish Siddiqui, Almas Jabeen, Rimsha Irshad, Farooq-Ahmad Khan, M. Iqbal Choudhary*, Yan Wang*. Structural transformation of methasterone with Cunninghamella blakesleeana and Macrophomina phaseolina. RSC Advances. 2022, 12 (15): 9494-9500.

13. Rimsha Irshad, Ahmed Saeed Ali Kabbashi, Kayode Muritala Salawu, Aziz-ur-Rehman, Yan-Gang Cao, Aneela Fayaz, Farooq-Ahmad Khan, Atia-tul-Wahab, M. Iqbal Choudhary, Yan Wang*. A new ent-clerodane diterpene from Detarium microcarpum Guill. & Perr. and its protective potential for osteoporosis. Fitoterapia. 2022, 160: 105226.

14. YongLing, Zhi-You Hao, Dong Liang, Chun-Lei Zhang, Yan-Fei Liu, Yan Wang*. The expanding role of pyridine and dihydropyridine scaffolds in drug design. Drug Design, Development and Therapy. 2021, 15: 4289-4338. (ESI高被引论文)

15. Yan Wang, Farooq-Ahmad Khan, Mahwish Siddiqui, Muhammad Aamer, Cong Lu, Atta-ur-Rahman, Atia-tul-Wahab*, M. Iqbal Choudhary*. The Genus Schefflera: a review of traditional uses, phytochemistry and pharmacology. Journal of Ethnopharmacology. 2021, 279: 113675.

16. Yan Wang, Muhammad Aamer, Meral Aslay, Bilge Sener*, Farooq-Ahmad Khan, Atia-tul-Wahab, Atta-ur-Rahman, Muhammad Iqbal Choudhary*. A new steroidal alkaloid from Fritillaria michailovskyi Fomin. Natural Product Research.2021, 36, 1: 361-366.

17. Muhammad Aamer, Sadaf Iqbal, Almas Jabeen, Malik Shoaib Ahmad, Mudassir Asrar, Sammer Yousuf, Atia-tul-Wahab, M. Iqbal Choudhary, Yan Wang*. Bioassay-guided isolation of anti-inflammatory constituents from Erigeron canadensis. Chemistry of Natural Compounds. 2021, 4: 638-640.

18. Yan Wang, Dong Liang, Farooq-Ahmad Khan, Chunlei Zhang, Yanfei Liu, Ruoyun Chen, M. Iqbal Choudhary, Dequan Yu*. Chemical constituents from Schefflera leucantha R.Vig. (Araliaceae). Biochemical Systematics and Ecology. 2020, 91, 104076.

19. Teng Xu, Cong Lu, Li Feng, Linxi Fan, Jing Sun, Bei Fan, Qiong Wang, Yan Wang*, Xinmin Liu*, Fengzhong Wang*. Liquid chromatography-mass spectrometry-based urinary metabolomics study on a rat model of simulated microgravity-induced depression. Journal of Pharmaceutical and Biomedical Analysis. 2019, 165: 31-40.

20. Guolin Yang#, Yan Wang#, Yiyi Yu, Jing Zheng, Shaoheng Li, Runyun Chen, Chunlei Zhang, Benjamin Naman, Dequan Yu*, Zhengyu Cao*. Schekwanglupaside C, a new lupane saponin from Schefflera kwangsiensis, is a potent activator of sarcoplasmic reticulum Ca2+-ATPase, Fitoterapia.2019, 137: 104150.

21. Yan Wang, Chunlei Zhang, Yanfei Liu, Dong Liang, Guoru Shi, Xin Wang, Ruoyun Chen, Fengzhong Wang*, Dequan Yu*. Sesquiterpenes and nor sesquiterpenes from Schefflera leucantha R.Vig. (Araliaceae). Biochemical Systematics and Ecology. 2019, 83: 7–9.

22. Cong Lu#, Yan Wang#, Teng Xu, Qi Li, Donghui Wang, Lijing Zhang, Bei Fan, Fengzhong Wang*, Xinmin Liu*. Genistein ameliorates scopolamine-induced amnesia in mice through the regulation of the cholinergic neurotransmission, antioxidant system and the ERK/CREB/BDNF signaling. Frontiers in Pharmacology. 2018, 9, Article 1153.

 科研项目(入职后)

 （1）国家重点实验室人才引进项目，基于代谢组学广西特色资源活性成分挖掘及结构修饰(CMEMR2023-A01)，50万元

 （2）广西师范大学科研启动经费，30万元

 （3）2024年度广西高校中青年教师科研基础能力提升项目，代谢组学导向鹅掌柴属五环三萜类镇痛成分的发现(2024KY0064)，3万元

招生方向

（1）化学生物学