电子邮箱：zn_sqhu@163.com

办公地址：广西师范大学化学与药学学院

基本介绍

        博士，副教授，硕士生导师（分析化学学硕、生物与医药专硕）。2019年6月毕业于中南大学，获化学（分析化学方向）专业博士学位。2018年5月至2019年5月，获国家留学基金委资助赴加拿大University of Waterloo进行博士联合培养。2019年7月起在广西师范大学化学与药学学院从事教学与科研工作。以第一作者或通讯作者分别在Chem. Sci.、Mater. Horiz.、Anal. Chem.、Chem. Commun.、ACS Appl. Mater. Interfaces、J. Hazar. Mater.等国际学术期刊发表SCI论文二十余篇，获授权发明专利3项。作为项目负责人主持国家自然科学基金、广西自然科学基金、广西科技基地和人才专项项目等多项项目。

研究方向

（1）纳米传感界面分析；

（2）POCT技术开发；

（3）光控生物传感、生物成像及药物递送。

讲授课程

（1）本科生课程：《分析化学》、《分析化学实验》、《药物分析实验》、《仪器分析实验》

（2）研究生课程：《表征技术》及《现代仪器分析实验》

论文专著

[20] Lianguo Geng, Xingdi Sun, Liuding Wang, Fengping Liu, Shengqiang Hu*, Shulin Zhao and Fanggui Ye*. Analyte-induced laccase-mimicking activity inhibition and conductivity enhancement of electroactive nanozymes for ratiometric electrochemical detection of thiram. J. Hazar. Mater., 2024, 463, 132936.

[19] Liuyan Zhou,‡ Xiaokun Li,‡Luyin Wang, Zhihong Zhou, Shengqiang Hu,* ShulinZhao, and Liangliang Zhang*. Fluid multivalentrecognition accelerating and boosting upconversion luminescence-activated DNAnanomachines for rapid andsensitive in vivo imaging. Anal. Chem., 2023, 95, 50, 18497-18503.

[18] Lianguo Geng, Shengqiang Hu*, Fengping Liu, Lu Liu, Xin He, Yangcan Wang, Yuhui Zhu, Hui Xu, Shulin Zhao and FangguiYe*. MOF-derivedmagnetic trimetallic oxide-carbon nanocomposites for modification-free and dualmolecular events-dependent ratiometric electrochemical analysis ofintracellular glutathione. Sensor Actuat. B.-Chem., 2023, 390, 134010.

[17] Lifang Pang,# Xiaolan Tang,# Lijia Yao, Liuyan Zhou, Shengqiang Hu*, Shulin Zhao and Liangliang Zhang*. Smart down/upconversion nanomachines integrated with “AND” logic computation and enzyme-free amplification for NIR-Ⅱ fluorescence-assisted precise and enhanced photodynamic therapy. Chem. Sci., 2023, 14, 3070-3075.

[16] Shengkai Zhang, Lijia Yao, Xiaofei Lv, Meijun Lu, Fengli Gao*, Liangliang Zhang, Shulin Zhao, and Shengqiang Hu*. Engineered Cancer Cells as Signal Probes for Fluorescence-Assisted Digital Counting Analysis.  Anal. Chem., 2023, 95,  4227-4234.

[15]  Shengqiang Hu,# Lixian Huang,# Liuyan Zhou, Tingchan Wu, Shulin Zhao, and Liangliang Zhang*. Single-Excitation Triple-Emission Down-/Up-Conversion Nanoassemblies for Tumor Microenvironment-Enhanced Ratiometric NIR-II Fluorescence Imaging and Chemo-/Photodynamic Combination Therapy. Anal. Chem., 2023, 95, 7, 3830-3839. (Cover Paper) 

[14]  Mengying Ye, Shengqiang Hu*, Liuyan Zhou, Xiaolan Tang, Shulin Zhao*, and Jingjin Zhao*.Fluidic Membrane Accelerating the Kinetics of Photoactivatable HybridizationChain Reaction for Accurate Imaging of Tumor-Derived Exosome. Anal. Chem., 2022, 94,  17645–17652.

[13] Wenchao Chen, Zhilian Tang, Shengqiang Hu*, Xinyao Yi, and Jianxiu Wang*. FUltraviolet CIrradiation-Induced Dehybridization of Double-Stranded Oligonucleotides:Mechanism Investigation and Label-Free Measurement of the Photodamage Level. Langmuir 2022, 38, 49, 15190–15197.

[12] Shengqiang Hu*,   Xue ting Fang,   Guijing Liu,   Guixiang Ma,   Fanggui Ye*  and  Shulin Zhao.  Gas pressure-assisted ratiometric atomic flame assay for point-of-care testing of tumor cell-derived exosomes. Analyst,  2022, 147, 48. (Cover Paper) 、( Analyst HOT Articles 2021)

[11] Lixian Huang,   Jinling Zhang,   Lifang Pang,   Shengqiang Hu*,   Liangliang Zhang*  and  Shulin Zhao. Reversible assembly-disassembly of plasmonic spherical nucleic acid enabling temperature-self-controllable and biomarker-activatable photothermal effect. Chem. Commun.,2021, 57, 11617. (Cover Paper) 

[10] Zhaohui Wei, Yuefan Yu, Shengqiang Hu*, Xinyao Yi, and Jianxiu Wang*. Bifunctional diblock DNA-mediated synthesis of nanoflower-shaped photothermal nanozymes for a highly sensitive colorimetric assay of cancer cells. ACS Appl. Mater. Interfaces. 2021, 13, 16801-16811. 

[9] Xueting Fang, Xiaoting Zhang, Zhihua Zhang, Shengqiang Hu,* Fanggui Ye* and Shulin Zhao. Complementary atomic flame/ molecular colorimetry dual-mode assay for sensitive and wide-range detection of cancer cells. Chem. Commun.,2021,57, 3327-3330. (Cover Paper)

[8] Shengqiang Hu, Po-Jung Jimmy Huang, Jianxiu Wang* and Juewen Liu*. Dissecting the effectof salt for more sensitive label-free colorimetric detection of DNA using gold nanoparticles. Anal. Chem., 2020, 92, 13354-13360.

[7] Shengqiang Hu, Tiantian Yi,Zhicheng Huang, Biwu Liu, Jianxiu Wang,* Xinyao Yi* and Juewen Liu*. Etching silvernanoparticles using DNA. Mater. Horiz., 2019, 6, 155-159.

[6] Shengqiang Hu,# Liujuan Tong,# Jianxiu Wang*, Xinyao Yi* and Juewen Liu*. NIR light-responsivehollow porous gold nanospheres for controllable pressure-based sensing and photothermaltherapy of cancer cells. Anal. Chem., 2019, 91, 15418-15424.

[5] Shengqiang Hu, Po-Jung Jimmy Huang, Jianxiu Wang* and Juewen Liu*. Phosphorothioate DNA mediated sequence-insensitive etching and ripening of silver nanoparticles. Front. Chem., 2019, 7, 198.

[4] Shengqiang Hu, Jianxiu Wang* and Juewen Liu*. Unified etching and protection of faceted silver nanostructures by DNA oligonucleotides. J. Phys. Chem. C,2019, 123, 12015-12022.

[3] Shengqiang Hu, Baoyu Ye, Hailin Tang, Fan Wu, Xinyao Yi, Tiantian Yi, Daohong Wu, Ling Wu and Jianxiu Wang*. Fabrication of multifunctional monometallic nanohybrids for reactive oxygen species-mediated cell apoptosis and enhanced fluorescence cell imaging. J. Mater. Chem. B, 2018, 6, 1187-1194.

[2] Lanshuang Hu,# Shengqiang Hu,# Linyan Guo, Congcong Shen, Minghui Yang,* and Avraham Rasooly*.DNA generated electric current biosensor. Anal.Chem., 2017, 89, 2547-2552.

[1] Shengqiang Hu, Baoyu Ye, Xinyao Yi, Zhize Cao, Daohong Wu, Congcong Shen, Jianxiu Wang*. Dumbbell-shaped metallothionein-templated silver nanoclusters with applications in cell imagingand Hg2+ sensing. Talanta, 2016, 155, 272-277.

科研项目

（3）国家自然科学基金地区基金：起止时间2024-01至2028-12、经费32.0万元、在研、主持。

（2）广西自然科学基金青年科学基金项目：起止时间2020-01至2022-12、经费8.0万元、在研、结题。

（1）广西科技基地和人才专项项目：起止时间2020-07至2023-06、经费10.0万元、在研、主持。

指导学生情况

（4）广西高等教育学会关于公布第十一届广西大学生化学实验技能竞赛(一等奖：覃幸唯、卢柳琴、蒋玉婷)

（3）“慕乐杯”第七届全国高等师范院校大学生化学实验邀请赛（一等奖：王雨馨、林洪敏、赵锦文）

（2）大学生创新创业训练计划项目（2020年度国家级：张志华、张晓婷；2021年度国家级：马桂香、刘桂菁、吕晓菲、卢美君；2022年度区级：姚力嘉、孙欣笛、吴新宇、林佳玲、梁小凤）

（1）广西师范大学本科生毕业论文（设计）（2021届：郑永鑫、邓雪凤、邓黎、程恒斌、罗贤柳、李应蛟；2022届：张志华、张晓婷、罗远薇、罗福卉、黄志莎、郭若琪；2023届：王杨灿、刘桂菁、蓝露露、卢冬晓）