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天然药物化学、天然产物化学生物学

2009.9–2012.7，中国医学科学院 & 北京协和医学院药物研究所，药物化学专业，理学博士学位；

2006.9–2009.7，沈阳药科大学中药学院，天然药物化学专业，理学硕士学位；

2002.9–2006.7，云南中医药大学中药学院，制药工程专业，工学学士学位。

天然药物化学、波谱分析

独立工作以来发表的SCI论文 (*为通讯作者, #为共同第一作者)：

1. Yuan-kun Zheng#, Ya-qi Wang#, Bao-jun Su, Heng-shan Wang, Hai-bing Liao*, Dong Liang*. New enantiomeric lignans and new meroterpenoids with nitric oxide release inhibitory activity from Piper puberulum. Bioorganic Chemistry, 2022, 119, 105522.

2. Ya-Jie Hu, Qian Lan,Bao-Jun Su, Zhen-Feng Chen, Dong Liang*. Structurally diverse abietane-type diterpenoids from the aerial parts of Gaultheria leucocarpa var. yunnanensis. Phytochemistry, 2022, 201, 113255.

3. Si-Wei Rao, Yuan-Yuan Duan, Hai-Qing Pang, Shao-Hua Xu,Shou-Qian Hu, Ke-Guang Cheng, Dong Liang*, Wei Shi*. Spectrum-Effect Relationship Analysis of Bioactive Compounds in Zanthoxylum nitidum (Roxb.) DC. by Ultra-High Performance Liquid Chromatography Mass Spectrometry Coupled With Comprehensive Filtering Approaches. Frontiers in Pharmacology, 2022,13, 794277.

4. Feng Qin#, Lumei Dai#, Bin Zhang, Rizhen Huang, Fanfan Wang, Jiangke Qin, Dong Liang*, Hengshan Wang*. (±)-Corysaxicolaine A: a pair of antitumor enantiomeric alkaloid dimers from Corydalis saxicola. Organic & Biomolecular Chemistry, 2022, 20,1396‒1400.

5.Fan Yang, Hua Li, Yan-Qiu Yang, Yue Hou, Dong Liang*. Lignanamides from the stems of Piper hancei maxim. and their anti-inflammatory and cytotoxic activities. Fitoterapia, 2022, 161, 105231.

6. Feng Qin#, Mei-Shan Li#, Jin-Jun Li, Yue Wang, Ke Wang, Jian-Yu Zhou, Dong Liang*, Heng-Shan Wang*. Four New Sesquiterpenoids from Zanthoxylum nitidum. Chemistry & Biodiversity, 2022, 19, e202200449.

7. Ya-Jie Hu, Man-Lan Chen, Dong Liang*. Lignans and terpenoids from Gaultheria leucocarpa var. yunnanensis and their anti-inflammatory and antioxidant activities. Fitoterapia, 2022, 162,105293.

8. Shuang He, Man-Lan Chen, Fan Yang, Dong Liang*. Piperhancosides A−C, new lignan glycosides from the stems of Piper hancei Maxim. Phytochemistry Letters, 2022, 50, 45‒49.

9. Fan Yang#, Bao-Jun Su#, Ya-Jie Hu#, Jin-Long Liu, Hua Li, Ya-Qi Wang, Hai-Bing Liao, Dong Liang*. Piperhancins A and B, Two Pairs of Antineuroinflammatory Cycloneolignane Enantiomers from Piper hancei. The Journal of Organic Chemistry, 2021, 86, 5284‒5291.

10. Feng Qin#, Cai Yi Wang#, Donghwa Kim, Heng-Shan Wang, Yan-Kui Zhu, Sang Kook Lee*, Gui-Yang Yao*, Dong Liang*. Nitidumpeptins A and B, Cyclohexapeptides Isolated from Zanthoxylum nitidum var. tomentosum: Structural Elucidation, Total Synthesis, and Antiproliferative Activity in Cancer Cells. The Journal of Organic Chemistry, 2021, 86, 1462‒1470.

11. Yuan-kun Zheng#, Bao-jun Su#, Ya-qi Wang, Heng-shan Wang, Hai-bing Liao*, Dong Liang*. New Tyramine- and Aporphine-Type Alkamides with NO Release Inhibitory Activities from Piper puberulum. Journal of Natural Products, 2021, 84,1316‒1325.

12. Hai-Yan Zhao#, Qian Lan#, Shuang He, Bao-Jun Su, Ya-Qi Wang, Hai-Bing Liao, Heng-Shan Wang, Dong Liang*. Chebulic acid derivatives from Balakata baccata and their antineuroinflammatory and antioxidant activities. Bioorganic Chemistry, 2021, 116, 105332.

13. Hai-Yan Zhao, Qian Lan, Ya-Qi Wang, Hai-Bing Liao, Heng-ShanWang, Dong Liang*. New lignans and a phenylpropanoid from Triadica rotundifolia and their antineuroinflammatory and antioxidant activities. Phytochemistry Letters, 2021, 45, 52‒56.

14. Hai-Yan Zhao, Ya-Qi Wang, Yan-Cai Li, Qian Lan, Hai-Bing Liao, Heng-Shan Wang, Dong Liang*. Flavonol glycosides and phenylpropanoid glycosides with inhibitory effects on microglial nitricoxide production from Neoshirakia japonica. Fitoterapia, 2021, 151, 104877.

15. Feng Hu#, Ya-Jie Hu#, Bao-Jun Su, Ya-Qi Wang, Hai-Bing Liao, Dong Liang*. Enantiomeric lignans with antineuroinflammatory activities from Mappianthus iodoides. Phytochemistry Letters, 2021, 42, 18‒23.

16. Hai-Yan Zhao, Bao-Jun Su, Wang-Jing Zhou, Ya-Qi Wang, Hai-Bing Liao, Heng-Shan Wang*, Dong Liang*. Diterpenoids and triterpenoids from Triadica rotundifolia and their effects on microglial nitric oxide production. Bioorganic Chemistry, 2020, 105, 104332.

17. Zi-Ni Yang#, Bao-Jun Su#, Ya-Qi Wang, Hai-Bing Liao*, Zhen-Feng Chen, Dong Liang*. Isolation, Absolute Configuration, and Biological Activities of Chebulic Acid and Brevifolincarboxylic Acid Derivatives from Euphorbia hirta. Journal of Natural Products, 2020, 83, 985‒995.

18. Cui He#, Yaqi Wang#, Tingmi Yang#, Hengshan Wang, Haibing Liao*, Dong Liang*. Quassinoids with Insecticidal Activity against Diaphorina citri Kuwayama and Neuroprotective Activities from Picrasma quassioides. Journal of Agricultural and Food Chemistry, 2020, 68, 117‒127.

19. Cai Yi Wang, Donghwa Kim, Yan Kui Zhu, Dong-Chan Oh, Ri ZhenHuang, Heng-Shan Wang, Dong Liang*, Sang Kook Lee*. Glechomanamides A−C, Germacrane Sesquiterpenoids with an Unusual Δ8‑7,12-Lactam Moiety from Salvia scapiformis and Their Antiangiogenic Activity. Journal of Natural Products, 2019, 82, 3056‒3064.

20. Jin-Long Liu, Min Yu, Hai-Bing Liao, Ting Liu, Yan-Hui Tan, Dong Liang*, Gui-Jie Zhang*. Sesquiterpenesand diterpenes from Euphorbia thymifolia. Fitoterapia, 2019, 139, 104408.

21. Xi-Lin Ouyang, Wen-Hua Mao, Chun-Gu Wang, Ying-Ming Pan, Dong Liang*, Heng-Shan Wang*. Five 11α, 12α-epoxy pentacyclictriterpenoid saponins with antithrombus activities from Glechoma longituba. Fitoterapia, 2019, 138, 104345.

22. Hai-Bing Liao, Wu-Ying Feng, Heng-Shan Wang, Dong Liang*. Sesquiterpenoid compounds from Curcuma kwangsiensis. Chemistry & Biodiversity, 2019, 16, e1900123.

23. Shan-Shan Zhu, Gui-Jie Zhang, Hai-Bing Liao, Heng-Shan Wang, Dong Liang*. A new chlorinated diphenylether and a new sesquilignan from the stems of Mappianthus tomentosus. Phytochemistry Letters, 2019, 30, 49‒52.

24. Yong-Li Zhang#, Qi-Min Pan#, Hai-Bing Liao, Jiang-Ke Qin, Ning Li, Dong Liang*, Gui-Jie Zhang*. Coumarinolignoids and lignanoids from the stems and leaves of Sapium discolor. Fitoterapia, 2019, 133, 17–22.

25. Gui-Jie Zhang#, Qi-Ming Pan#, Yong-Li Zhang, Hai-Bing Liao,Yan-Qiu Yang, Yue Hou*, Dong Liang*. Coumarinolignoids and Taraxerane Triterpenoids from Sapium discolor and Their Inhibitory Potential on Microglial Nitric Oxide Production. Journal of Natural Products, 2018, 81, 2251–2258.

26. Huan Jiang, Gui-Jie Zhang, Hai-Bing Liao*, Dong Liang*. New terpenoid and phenylpropanoid glycosides from Tinospora sinensis. Fitoterapia, 2018, 131, 127–133.

27. Yuan Zhu#, Ri-Zhen Huang#, Chun-Gu Wang, Xi-Lin Ouyang, Xiao-Teng Jing, Dong Liang*, Heng-Shan Wang*. New inhibitors of matrix metalloproteinases 9 (MMP-9): Lignans from Selaginella moellendorffii. Fitoterapia, 2018, 130, 281–289.

28. Shu-Lin Zhang, Ri-Zhen Huang, Hai-Bing Liao*, Heng-Shan Wang, Zhen-Feng Chen, Dong Liang*. Cyclic pentapeptidetype compounds from Clerodendrum japonicum (Thunb.) Sweet. Tetrahedron Letters, 2018, 59, 3481–3484.

29. Chun-Gu Wang#, Wei-Na Yao#, Bin Zhang, Jing Hua, Dong Liang*, Heng-Shan Wang*. Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration. Bioorganic & Medicinal Chemistry Letters, 2018, 28, 2413–2417.

30. Shu-Lin Zhang#, Zi-Ni Yang#, Cui He, Hai-Bing Liao*, Heng-Shan Wang, Zhen-Feng Chen, Dong Liang*. Oleanane-typetriterpenoid saponins from Lysimachia fortunei Maxim. Phytochemistry, 2018, 147, 140–146.

31. Gui-Jie Zhang#, Feng Hu#, Huan Jiang, Lu-Mei Dai, Hai-Bing Liao, Ning Li, Heng-Shan Wang, Ying-Ming Pan*, Dong Liang*. Mappianines A–E, structurally diverse monoterpenoid indole alkaloids from Mappianthus iodoides. Phytochemistry, 2018, 145, 68–76.

32. Lu-Mei Dai#, Ri-Zhen Huang#, Bin Zhang, Jing Hua, Hai-Bing Liao, Heng-Shan Wang*, Dong Liang*. Three new triterpenoid saponins from the aerial parts of  Lysimachia foenum-graecum. Phytochemistry Letters, 2017, 22, 133–137.

33. Wei-Na Yao#, Ri-Zhen Huang#, Jing Hua, Bin Zhang, Chun-Gu Wang, Dong Liang*, Heng-Shan Wang*. Selagintamarlin A: A Selaginellin Analogue Possessing a 1H‑2-Benzopyran Core from Selaginella tamariscina. ACS Omega, 2017, 2, 2178–2183.

34. Huan Jiang, Gui-Jie Zhang, Yan-Fei Liu, Heng-Shan Wang, Dong Liang*. Clerodane Diterpenoid Glucosides from the Stems of Tinospora sinensis. Journal of Natural Products, 2017, 80, 975–982.

35. Lu-Mei Dai#, Ri-Zhen Huang#, Bin Zhang, Jing Hua, Heng-Shan Wang*, Dong Liang*. Cytotoxic triterpenoid saponins from Lysimachia foenum-graecum. Phytochemistry, 2017, 136, 165–174.

36. Bin Zhang#, Ri-Zhen Huang#, Jing Hua, Hong Liang, Ying-MingPan, Lu-Mei Dai, Dong Liang*, Heng-Shan Wang*. Antitumor lignanamides from the aerial parts of Corydalis saxicola. Phytomedicine, 2016, 23, 1599–1609.

37. Qi-Ming Pan#, Gui-Jie Zhang#, Ri-Zhen Huang, Ying-Ming Pan,Heng-Shan Wang, Dong Liang*. Cytisine-type alkaloids and flavonoids from the rhizomes of Sophora tonkinensis. Journal of Asian Natural Products Research, 2016, 18, 429–435.

38. Qi-Ming Pan, Yu-Huan Li, Jing Hua, Fu-Ping Huang, Heng-ShanWang, Dong Liang*. Antiviral Matrine-Type Alkaloids from the Rhizomes of Sophora Tonkinensis. Journal of Natural Products, 2015, 78, 1683–1688.

发明专利：

1. 梁东, 张贵杰, 潘其明, 廖海兵. 蒲公英烷型三萜及其制备方法和用途. 中国发明专利, 授权号ZL201810778118.5.

2. 梁东, 张贵杰, 潘其明, 廖海兵. 香豆素并木脂素及其制备方法和用途. 中国发明专利, 授权号ZL201810777517.X.

3. 王恒山, 梁东, 姚维娜, 黄日镇, 王春姑, 潘英明, 张斌, 代禄梅. 一种含吡喃环酚类化合物及其制备方法和应用. 中国发明专利, 授权号ZL201710053753.2.

4. 潘英明, 杨漓, 梁东. 治疗高尿酸血症的中药及其制备方法. 中国发明专利, 申请号201610549816.9.

1. 国家自然科学基金面上项目，胡椒属N-肉桂酰吡咯型生物碱基于神经炎症/氧化应激双重抑制抗缺血性脑卒中的研究（22177021），2022/1-2025/12，60万元，在研，主持。

2. 国家自然科学基金地区项目，瑶药山蒟和毛蒟中新木脂烷型小胶质细胞活化抑制剂的发现及其抗AD作用机制研究（81960634），2020/1-2023/12，34万元，在研，主持。

3. 国家自然科学基金地区项目，三种广西特色珍珠菜属植物中抗肿瘤三萜皂苷及其构效关系和作用机制研究（21462006），2015/1-2018/12，53万元，已结题，主持。

4. 国家自然科学基金青年项目，广西产定心藤属植物中新颖结构β-咔啉生物碱的发现及其抗肿瘤活性研究（81402817），2015/1-2017/12，24万元，已结题，主持。

5. 广西自然科学基金杰出青年项目，广西瑶药抗神经炎症天然产物化学（2017GXNSFFA198004），2017/9-2021/9，60万元，在研，主持。

1. 广西第一批八桂青年学者（天然药物化学）

2. 2017年度广西自然科学杰出青年基金获得者

3. 广西师范大学第五届教学新秀