电子邮箱：xcshen@mailbox.gxnu.edu.cn 

基本介绍

沈星灿，广西师范大学教授/博士生导师，广西师范大学副校长。教育部“新世纪优秀人才支持计划”入选者、自治区“八桂学者”、广西“新世纪十百千人才工程”第二层次人选、广西教学名师；中国生物材料学会智能仿生生物材料分会副主任委员、广西化学化工学会常务理事、广西化工与制药教指委副主任委员。生物智能纳米材料广西创新团队学术带头人，长期从事生物材料及其应用研究。先后主持国家自然科学基金项目6项，广西自然科学基金杰青项目、广西自然科学基金创新团队、重点项目等省级项目多项。在Nat. Commun.、Angew. Chem. Int. Ed.、JACS、ACS Nano、Biomaterials、Chem. Sci.、《中国科学·化学》等权威学术期刊发表SCI论文140多篇，正面他引逾3千次，个人H因子35，授权国家发明专利20多项；入选全球前2% 的顶尖科学家。以主要完成人，先后获广西特别贡献奖1项、广西科技进步一等奖1项、广西自然科学二等奖2项、广西壮族自治区级教学成果奖一等奖3项，二等奖2项。

研究方向

1. 生物材料及其生物效应的研究

2. 纳米材料表/界面性质及其生物效应

3. 具有肿瘤诊治功能的“智能”生物材料的设计与合成

讲授课程

（1）本科生课程：《无机化学》、《综合化学实验》等

（2）研究生课程：《生物大分子》、《生物材料》等

近五年来的代表性论文

2025年

1.Wei F, Liang J, Shen X C, et al. Recent advances in the development of metallodrugs for cancer chemoimmunotherapy. Coordination Chemistry Reviews, 2025, 526, 216319.

2.Hu B, Liu Q, Jiang Y, et al. NIR‐II Fluorescence/Photoacoustic Dual Ratiometric Probes with Unique Recognition Site for Quantitatively Visualizing H₂S₂ in Vivo. Angewandte Chemie International Edition, 2025, e202418378.

3.Chen W, Feng H, Mo Y, et al. Hyaluronic acid-functionalized ruthenium photothermal nanoenzyme for enhancing osteosarcoma chemotherapy: Cascade targeting and bidirectional modulation of drug resistance. Carbohydrate Polymers, 349 (2025) 122945

4.Wang A, Li L, Zheng L, et al. A universal gelation strategy of bivalent anions to construct nanofibrous lysozyme hydrogels for immunomemory anti‐recurrence of diabetic wound infection by activating the cGAS‐STING pathway. Aggregate, 2025, 6(1), e662.

2024年

1. Jiang Y, Wang L, Hu B, et al. Engineering of Kidney‐Targeting Fluorophores with Tunable Emission from NIR‐I to NIR‐II for Early Diagnosis of Kidney Disease. Advanced Healthcare Materials, 2024, 13(32), 2402828.

2. Zhu C, Li J, Sun W, et al. Signaling Mechanism of Cuproptosis Activating cGAS-STING Immune Pathway. JACS Au, 2024, 4(10), 3988-3999.

3. Xu J, Lv Z, Wang L, et al. Tuning Tumor Targeting and Ratiometric Photoacoustic Imaging by Fine‐Tuning Torsion Angle for Colorectal Liver Metastasis Diagnosis. Chemistry–A European Journal,2024, 30(55), e202402019.

4. Wang A, Li L, Zheng L, et al. A universal gelation strategy of bivalent anions to construct nanofibrous lysozyme hydrogels for immunomemory anti‐recurrence of diabetic wound infection by activating the cGAS‐STING pathway. Aggregate, 2025, 6(1), e662.

5. Liu H, Gao C, Xu P, et al. Biomimetic Gold Nanorods‐Manganese Porphyrins with Surface‐Enhanced Raman Scattering Effect for Photoacoustic Imaging‐Guided Photothermal/Photodynamic Therapy.Small, 2024, 20(42), 2401117.

6. Qiu H, Wang S, Huang R, et al. Acidity-responsive polyphenol-coordinated nanovaccines for improving tumor immunotherapy via bidirectional reshaping of the immunosuppressive microenvironment and controllable release of antigens. Biomaterials Science, 2024, 12(12), 3175-3192.

7. Wei F, Liang J, Tan Z, et al. Rhenium (I) coordinated carbon nitride as type II immunogenic cell death inducers for enhancing photoimmunotherapy against triple-negative breast cancer. Chemical Engineering Journal, 2024, 485, 150154.

8. Wang Y, Liu T, Zhang Y Y, et al. Cross-catenation between position-isomeric metallacages.Nature Communications, 2024, 15(1), 1363.

9. Wei, F.; Karges, J.; Gao, S.; Wang, L.; Zhang, X.; Shen, X.-C.; Ji, L.; Chao, H. Two-photon phototriggering of ROS storm in ruthenium(II) coordinated carbon nitride for robust cancer immunotherapy. Nano Today 2024, 54, 102066.

10. Zhao, D.; Li, Z.; Zhu, K.; Lu, A.; Wang, Y.; Jiang, J.; Tang, C.; Shen, X.-C.; Ruan, C. Highly dispersed amorphous nano-selenium functionalized carbon nanofiber aerogels for high-efficient uptake and immobilization of Hg (II) ions. J. Hazard. Mater., 2024, 465, 133162.

11. Wang, L.; He, M.; Liu, X.; Jiang, B.-P.; Chen, H.; Shen, X.-C. Dual-labeled single fluorescent probes for the simultaneous two-color visualization of dual organelles and for monitoring cell autophagy. Anal. Chem., 2024, 96, 876-886.（IF7.4）

2023年

(1)  Zhang, L.; Yang, A.; Ruan, C.; Guo, X.; Liang, H.; Kuo, W.-S.; Shen, X.-C.; Jiang, B.-P. Copper-Nitrogen-Coordinated Carbon Dots: Transformable Phototheranostics from Precise PTT/PDT to Post-Treatment Imaging-Guided PDT for Residual Tumor Cells. ACS Appl. Mater. Interfaces 2023, 15, 3253-3265. （IF9.5）

(2)  Ye, Y.; He, M.; Wang, L.; Shen, X.-C.; Chen, H. Unexpected dual-functional cyanine fluorophores: NIR multifunctional fluorescent probes for simultaneous monitoring of mitochondrial cysteine/viscosity during kidney ferroptosis in vivo. Sens. Actuators B-Chem., 2023, 396, 134600.

(3)  Xu, P.; Wen, C.; Gao, C.; Liu, H.; Li, Y.; Guo, X.; Shen, X.-C.; Liang, H. Near-Infrared-II-Activatable Self-Assembled Manganese Porphyrin-Gold Heterostructures for Photoacoustic Imaging-Guided Sonodynamic-Augmented Photothermal/Photodynamic Therapy. ACS Nano 2023, 18, 713-727. （IF17.1）

(4)  Wang, A.; Li, H.; Feng, H.; Qiu, H.; Huang, R.; Wang, Y.; Ji, S.; Liang, H.; Shen, X.-C.; Jiang, B.-P. In Situ Polymerization of Aniline Derivative in Vivo for NIR-II Phototheranostics of Tumor. ACS Appl. Mater. Interfaces 2023, 15, 5870-5882.

(5)  Tang, S.; Zhou, B.; Sun, W.; Zhu, C.; Tang, Y.; Jiang, B.-P.; Shen, X.-C. Glutathione depletion-mediated in situ transformation of Prussian blue nanocubes for enhanced tumor-specific imaging and photoimmunotherapy. Inorg. Chem, Front., 2023, 10, 4054-4064.

(6)  Sun, W.; Zhu, C.; Song, J.; Ji, S.-C.; Jiang, B.-P.; Liang, H.; Shen, X.-C. Hydrogen Sulfide Gas Amplified ROS Cascade: FeS@GOx Hybrid Nanozyme Designed for Boosting Tumor Chemodynamic Immunotherapy. Adv Healthc Mater., 2023, 12, 2300385.

(7)  Meng, N.; Xu, P.; Wen, C.; Liu, H.; Gao, C.; Shen, X. C.; Liang, H. Near-infrared-II-activatable sulfur-deficient plasmonic Bi2S3-x-Au heterostructures for photoacoustic imaging-guided ultrasound enhanced high performance phototherapy. J. Colloid Interface Sci., 2023, 644, 437-453.

(8)  Liu, L.; Wang, L.; Tan, B.; Wu, X.; Chen, H.; Shen, X.-C. A robust ratiometric photoacoustic and fluorescence dual-modal molecular probe for capturing endogenous HNO generation in tumor mice model. Sens. Actuators B-Chem., 2023, 384, 133646.

(9)  Bao, X.; Lu, D.; Wang, Z.; Yin, H.; Zhu, B.; Chen, B.; Shi, M.; Zhang, Y.; Xu, Q.; Qin, Y.; Shen, X.-C.; Wu, K. Significantly enhanced photothermal catalytic CO₂ reduction over TiO₂g-C₃N₄ composite with full spectrum solar light. J. Colloid Interface Sci., 2023, 638, 63-75.

(10)  Zhang, H.; Zhu, C.; Liang, J.; Li, S.; Hu, L.-F.; Liang, H.; Kuo, W.-S.; Shen, X.-C. Smart phototheranostics based on carbon nanohorns for precise imaging-guided post-PDT toward residual tumor cells after initial phototherapy. Chem. Eur. J., 2023, 29.

2022年

(1)  Zhang, S.; Chen, H.; Wang, L.; Qin, X.; Jiang, B.-P.; Ji, S.-C.; Shen, X.-C.; Liang, H. A General Approach to Design Dual Ratiometric Fluorescent and Photoacoustic Probes for Quantitatively Visualizing Tumor Hypoxia Levels In Vivo. Angew. Chem. Int. Ed. 2022, 61, e202107076.

(2)  Zhu, C.; Guo, Z.; Yang, A.; Jiang, B.-P.; Liang, H.; Shen, X.-C. The precise anti-tumor effect of a metallopolysaccharide-based nanotheranostic: turning phototherapy into programmed chemotherapy. Inorg. Chem. Front., 2022, 9, 1869-1878.

(3)  Zhu, C.; Wang, Y.; Li, Z.; Sun, W.; Jiang, B.-P.; Shen, X.-C. Metallopolysaccharide-Based Smart Nanotheranostic for Imaging-Guided Precise Phototherapy and Sequential Enzyme-Activated Ferroptosis. Biomacromolecules 2022, 23, 2007-2018.

(4)  Wang, A.; Fan, G.; Qi, H.; Li, H.; Pang, C.; Zhu, Z.; Ji, S.; Liang, H.; Jiang, B.-P.; Shen, X.-C. H₂O₂-activated in situ polymerization of aniline derivative in hydrogel for real-time monitoring and inhibition of wound bacterial infection. Biomaterials 2022, 289, 121798.

(5)  Liu, L.; Xu, J.; Zhang, S.; Chen, H.; Wang, L.; Shen, X.-C.; Chen, H. Rational design of dual ratiometric photoacoustic and fluorescent probe for reliable imaging and quantitative detection of endogenous CO during drug-induced liver injury and repair. Sens. Actuators B-Chem., 2022, 367, 133171.

(6)  Liu, L.; Liu, C.; Wang, L.; Shen, X.-C.; Chen, H. A disaggregation-induced emission strategy to obtain dual-emission fluorescence-enhanced probe for visualization of SO₂ fluctuation in living cells, tumor tissue and zebrafish. Sens. Actuators B-Chem., 2022, 371, 132542.

(7)  Gao, C.; Jian, J.; Luo, L.; Liang, J.; Li, Z.; Pang, M.; Cai, H.; Shen, X.-C. Single-walled carbon nanohorns-based smart nanotheranostic: From phototherapy to enzyme-activated fluorescence imaging-guided photodynamic therapy. J. Colloid Interface Sci., 2022, 628, 273-286. 

2021年

(1)  Zhang, L.; Zhu, C.; Huang, R.; Ding, Y.; Ruan, C.; Shen, X.-C. Mechanisms of reactive oxygen species generated by inorganic nanomaterials for cancer therapeutics. Front. Chem., 2021, 9, 630969.

(2)  Yi, S.; Deng, S.; Guo, X.; Pang, C.; Zeng, J.; Ji, S.; Liang, H.; Shen, X.-C.; Jiang, B.-P. Red emissive two-photon carbon dots: Photodynamic therapy in combination with real-time dynamic monitoring for the nucleolus. Carbon, 2021, 182, 155-166.

(3) Wen, C.; Chen, H.; Guo, X.; Lin, Z.; Zhang, S.; Shen, X.-C.; Liang, H. Lysosome-targeted gold nanotheranostics for in situ SERS monitoring pH and multimodal imaging-guided phototherapy. Langmuir, 2021, 37, 569-577.

(4)  Guo, X.; Wen, C.; Xu, Q.; Ruan, C.; Shen, X.-C.; Liang, H. A full-spectrum responsive B-TiO₂@SiO₂-HA nanotheranostic system for NIR-II photoacoustic imaging-guided cancer phototherapy. J. Mater. Chem. B, 2021, 9, 2042-2053.

(5)  Gao, C.; Guo, W.; Guo, X.; Ding, Z.; Ding, Y.; Shen, X.-C. Black SnO_2-x based nanotheranostic for imaging-guided photodynamic/photothermal synergistic therapy in the second near-infrared window. Acta Biomateri., 2021, 129, 220-234.

(6)  Ding, Y.; Huang, R.; Luo, L.; Guo, W.; Zhu, C.; Shen, X.-C. Full-spectrum responsive WO_3-x@HA nanotheranostics for NIR-II photoacoustic imaging-guided PTT/PDT/CDT synergistic therapy. Inorg. Chem. Front., 2021, 8, 636-646.

科研项目

先后主持国家自然科学基金项目6项，广西自然科学基金杰青项目、广西自然科学基金创新团队等项目。

近年承担主要项目：

1.国家自然科学基金（面上项目），仿生杂化金属酶及其调控TrxR增效级联催化抗肿瘤的研究，2024-01至2027-12

2. 国家自然科学基金（面上项目），程序性肿瘤纳米诊疗剂及其时间有序精准响应机制，2020-1至2023-12

3. 广西自然科学基金（创新研究团队项目），纳米生物材料的仿生构筑与智能响应，2017至2022-01

奖项：

1. 梁宏，陈振锋，杨峰，沈星灿，边贺东，梁福沛，刘延成，曾明华，陈自卢，黄克斌，覃其品，张耀；广西科学技术奖特别贡献奖（特等奖）：基于DNA、蛋白质靶标新型抗肿瘤活性化合物的发现；2018年，广西壮族自治区政府

2. 梁宏，沈星灿，边贺东，何锡文，蒋治良；广西科技进步奖一等奖：模型蛋白质与靶物的相互作用及后续效应研究；2009年，广西壮族自治区政府

3. 电催化剂的表面与载体结构设计、制备及其在燃料电池和电化学传感中的应用，主要完成单位：广西师范大学、厦门大学，主要完成人员：樊友军、孙世刚、沈星灿、韦 露、钟静萍、王睿翔，自然科学奖二等奖

4. 2017年沈星灿教授主持的《构建西部优质化学专业,创新“一制二化三能四课”拔尖人才培养模式》项目获得自治区级教学成果一等奖证书

5. 2021年邱建华教授组织申报的《高师院校化学一流专业“一核心两主线三保障四途径”人才培养体系构建与实践》项目在广西高等教育自治区级教学成果奖评定中获得一等奖。 排名第二

6. 2013 广西青年五四奖章获得者 共青团广西区委、广西青年联合会授予全区优秀青年、青年集体的最高奖项

课题组招收（高分子化学与物理、生物与医药、化学生物学等专业的硕博研究生，以及对科研感兴趣的本科生，欢迎联系、报考！